|Patent #||Title||Related Products|
|10,054,532||Particle sensor with interferent discrimination||proBE3000, miniBE, OD Scanner|
|9,752,974||Particle sensor with interferent discrimination||proBE3000, miniBE, OD Scanner|
|8,603,772||Particle sensor with wide linear range||BE2100|
|8,405,033||Optical sensor for rapid determination of particulate concentration||proBE3000, miniBE, OD Scanner|
|7,100,462||Self-adjusting sensor mounting device||BE2100, miniBE|
Particle sensor with interferent discrimination
This invention provides methods and devices to measure particle suspension concentrations in the presence of potential interferents. Particle back-scatter readings are taken at light wavelengths that are absorbed by the medium before interacting with surrounding objects. Source-detector spacings are minimized compared to the mean absorbance path length of light, thereby maximizing the range of sensitivity to particle concentration. Discrimination against potentially interfering particles, such as bubbles, is provided by mapping the signal distribution against the central signal value and/or by the use of statistical measures with reduced dependence on outliers. The methods and devices allow accurate particle concentration readings over a wide range of concentration in environments crowded with potentially interfering objects and in the presence of variable concentrations and sizes of potentially interfering particles.
Particle sensor with wide linear range
This invention provides a novel methods and devices for measurement of particle concentration or changes in particle concentration over a wide linear range. The invention comprises one or more radiation sources and one or more detectors contained in a housing which is interfaced to a medium containing particulate matter. The one or more radiation sources are directed into the medium, scattered or transmitted by the particulate matter, and then some portion of the radiation is detected by the one or more detectors. Methods for confining the measurement to a specific volume within the medium are described. Algorithms are provided for combining the signals generated by multiple source-detector pairs in a manner that results in a wide linear range of response to changes in particle concentration. In one embodiment the sensor provides non-invasive measurements of biomass in a bioreactor. In another embodiment an immersible probe design is described, which may be suited for one-time use. In an addition embodiment, a sensor is provided which is well suited to the rapid sequential measurement of particle concentration in multiple vessels, such as assessment of biomass in series of shake flasks.
Optical sensor for rapid determination of particulate concentration
This invention provides methods and devices to measure particle suspension concentrations through the side wall of a container. Particle back-scatter readings are taken at light wavelengths that do not travel far through the medium. Detected scatter is related to actual particle concentration or standard O.D. values. The methods and devices allow particle concentration readings through containers not normally intended for use in such assays.
Self-adjusting sensor mounting device
A method and device for mounting a sensor to a surface that is flat in one dimension and flat or curved in a second dimension. The mounting method results in stable self-centering attachment of the sensor to the surface across a wide range of radii in the second dimension of the surface. A fixed distance and angle between the sensor components and the surface is automatically maintained despite wide changes in the radius of the surface. An attachment means is provided that is secure, repeatable, and reusable. Additionally, a means of maintaining a clear unobstructed window between the sensor and surface is provided.