Compare BugLab Products

proBE 3000
(coming soon)
Sensor type Immersion Fiber optic Non-invasive Non-invasive Fiber optic Non-invasive Portable handheld
Vessel sizes Any size ≥1 L Smaller vessels and bioreactor bags 250–2000 mL shake flasks, 50 mL conical tubes
Vessel wall thickness N/A 6–13 mm <3 mm <5 mm
Reflectance spectrum 1310 nm 850 nm 1330 nm 1310 nm
Sensor placement measurement requirements >1 cm below media level and >3 cm from vessel bottom and/or interfering objects Fluid distance must be >7.5 cm from sensor >2 cm fluid depth   >3 cm fluid depth (fluid volume ~20% of vessel capacity)
Additional info Probe sizes, diameter/length
  • 3.2 mm/140 mm
  • 4 mm/205 mm
  • 4 mm/325 mm
  • 12 mm/120 mm
Monitoring options
  • Single sensor base unit
  • BE2400 Multiplex sensor base unit
  • BE/USB Adapter (no monitor)
Validated vessels
  • Applikon MiniBio 250, 500, 1000 mL
  • Eppendorf BioBLU
    0.3 f, 1 f, 3 f
Biomass OD range** OD 0.01 to 600, >4 orders OD <0.3 to >300, >3 orders OD <0.1 to >500, >3.5 orders OD <0.3 to >30, >2 orders
Biomass range (S. cerevisiae DCW) <0.01 to >200 g/L <0.1 to >100 g/L   <0.05 to >150 g/L   <0.1 to >10 g/L
Biomass accuracy* (S. cerevisiae  DCW ) 15% 0.03–200 g/L 15% 0.1–100 g/L 15% 0.1–150 g/L 15% 0.3–10 g/L
Factory-set standard calibration
  • S. cerevisiae
  • E. coli
  • NTU
  • Clostridium
User-defined to match specific vessel wall thickness
  • S. cerevisiae
  • S. cerevisiae
  • E. coli
  • NTU
  • Clostridium
  • Chlorella vulgaris
Available outputs Analog 4–20 mA or 2–10 V, USB Analog 4–20 mA or 2–10 V, RS-232/DB9, USB Analog 4–20 mA or 2–10 V, USB USB
Windows PC software interface Real-time via USB, OPC Real-time via USB, OPC Real-time via USB, OPC Download measurement data via USB
Performance verification Reflectance standards Calibration cups Reflectance standards Verification cup
Laser calibration Self-calibrating Self-calibrating Self-calibrating Self-calibrating
Multiplexing features N/A Up to 4 sensors per base unit Up to 4 sensors per base unit N/A
Special features Unique bubble compensation, autoclavable Measures through fermenter wall or viewing port Unique bubble compensation, small footprint <6 sec. measurement, cordless, rechargeable

** To report results in OD units, it will be necessary to calibrate the sensor to correlate with the specific spectrophotometer used for offline OD measurements.  This is due to differences in OD measured among varying spectrophotometers as OD itself is not an absolute universal value.

* 15% accuracy encompasses variations in vessel wall thickness, sizes, and physical condition. For the proBE 3000 and miniBE, the 15% accuracy also encompasses the effects of varying bubbling conditions due to aeration, sparging, foaming and/or agitation. In the absence of these variations, the accuracy will be better than 15%.