BugLab was founded in 2003 and has since established itself as the innovation leader in advancing optical monitoring of cell biomass during fermentation. BugLab’s unique sensors have been adopted worldwide and are used in various applications and industries including biopharma, bioenergy, biomaterials, food and beverage as well as microbiology research.
BugLab’s first product, the BugEye® 100, was the first of its class, of non-invasive biomass monitoring and was designed to yield highly accurate, real-time measurements of microbial biomass.
This product has been further refined and improved with the debut of several new monitoring devices. The BE2100 Biomass Monitor, designed to monitor cell growth in glass fermentors, as well as stainless steel vessels with glass viewing ports. This noninvasive sensor measures Optical Densities (OD) from 0.1 to 300+ without changing sensors, resulting in no risk of sensor fouling or culture contamination.
In 2011, BugLab launched the portable handheld OD monitor for shake flasks, the BEH100 OD Scanner. The use of this product has revolutionized how Optical Density can be quickly, and reliably measured, allowing the end user to have fast, efficient, and reliable ways to know what is happening inside their shake flask and culture bottle without having to take a sample.
Added in 2016 to BugLab’s unique family of sensors is the proBE 3000 immersive sensor, suitable for even the smallest of vessels. This offering has a highly effective patented bubble discernment algorithm that discerns between bubbles and cells which has previously been a limitation of all sensors offered in the marketplace. This unique biomass probe offers a complete solution to measure OD from 0 to over 600 OD with one single sensor. These special features separate itself from any other sensor in the marketplace.
In 2019, BugLab launched it’s latest innovation, the miniBE noninvasive sensor optimized for parallel multi-vessel biomass monitoring in small vessels and single use fermenters including bioreactor bags. The miniBE incorporates the same patented bubble correction feature as the proBE 3000 and measures OD from <0.1 to >300+ through the vessel wall with no sampling nor immersion port required. It’s small footprint and unique attachment allow for diverse vessel compatibility with working volumes down to 10 ml.
BugLab has also developed other similar products customized to help customers solve their unique biomass measurement challenges. Our patented sensor technology has also been adopted and integrated as an OEM component in various other fermentation monitoring systems.
Our commitment is dedicated to providing innovative and high quality products in the Biomass market, that are intuitive, and easy to use. Each of our products are individually manufactured, and put through a rigorous QC and testing procedure, right within BugLab’s facility in Northern California.
Classical Optical density measurements in a spectrophotometer, often requires dilution in order to determine the total biomass greater than 0.5 OD(600nm). BugLab’s technology operates on backlight scattering, utilizing multiple laser and detector pairs.
A near infrared (NIR) laser is injected into the medium and the interaction with cells scatters and reflects light. Photo-detectors collect light that is back-scattered from the cells. The intensity of the detected light is proportional to optical density allowing measurements of OD, without dilution or liquid handling, over a wide linear range. Due to this, BugLab’s technology gives highly accurate readings.
Measuring in the near infrared spectrum offers the additional advantage to the scientist by avoiding absorbance of light by colored vessels and colored media components such as in algal cultures.
BugLab currently offers the handheld OD Scanner which is most suitable for measuring an OD Range of 0-30 OD units, the noninvasive BE2100 and miniBE, which measures less than 0.1 to over 300 OD units, and the immersive proBE 3000 which measures 0 to over 600 OD units with one sensor. Our instruments are supplied with intuitive windows compatible software and USB connectivity that allows data download, analysis, calibration, parameter modification and real time data acquisition as well as real time data transfer and communication via analog output, serial protocol and OPC connectivity.
In order to determine which will work best for you, please visit our products page for more detail, or send us an email at email@example.com or visit our contact us page.